Figure 1.

Percent of aged ApoE^−/− mice sleeping huddled in the same quadrant decreased significantly in relation to young animals while no differences were detected in C57Bl/6 mice. Sleeping pattern of C57Bl/6 and ApoE^−/− mice with different age and sex (n = 10/sex/age/genotype) was evaluated twice daily over 5 consecutive days. Values are expressed as combined male and female data means ± SEM. Different letters (a,b,c) represent significant differences between groups (F(3/39) = 27.15, p = 0.000). Kruskal Wallis non-parametric one-way ANOVA and Tukey’s Multiple Comparison Tests. No differences were observed between sexes in both strains.