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. 2018 Mar 3;8(3):33. doi: 10.3390/bs8030033

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Reduction in exploratory behavior in open field is associated with aging in C57Bl/6 and ApoE^−/− mice (n = 10/sex/age/genotype) although knockout mice showed significantly decrease in exploratory activity compared with their age-matched wild-type controls. Values are expressed as combined male and female data means ± SEM. Different letters (a,b,c) represent significant difference between groups. (A) Vertical activity (steepness) (F(3/34) = 21.38, p = 0.000); (B) Visited corners. (F(3/23) = 16.38, p = 0.000). Kruskal Wallis nonparametric one-way ANOVA and Tukey’s Multiple Comparison Tests. No significant differences were found between sexes in both strains.