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IL-27 potentiates the upregulation of OAS2 and APOBEC3G (A3G) in uterine stromal fibroblasts. Confluent monolayers of fibroblasts were pretreated with IL-27 (1 and 100 ng/mL) for 48 h before washout and subsequent treatment with poly (I:C) (25 μg/mL) for 24 h, after which mRNA expression levels for OAS2 (A) and A3G (B) were measured by RT-PCR (n = 4). ***P < 0.001.
