Table 2.
Studies comparing decision-making in MS patients and HCs and baseline data of their respective cohorts.
| Cohort |
n MS/CIS |
n HC |
EDSS | MS-type | Disease duration (mean (SD)) |
Age in years (mean (SD)) |
Affective changes | Cognitive changes | Behavioural changes | Fatigue in MS patients |
|---|---|---|---|---|---|---|---|---|---|---|
| Farez et al. 2014 [18] | 27 | 27 | Mean: 1.03 (SD 0.8) | RR | 7.9 months (8.1) | 33.3 (9.7) | − | + | Nm | Nm |
|
| ||||||||||
| Simioni et al. 2012 [26] | 72 | 38 | Mean: 1.9 (SD: 0.5, range: 1.5–3) | RR | 5.06 years (3.3) | 34.6 (6.3) | + | + | − | Nm |
|
| ||||||||||
| Muhlert et al. 2014 [21] | 105 | 43 | Median: 5 (range: 0–8.5) | RR (n = 61), SP (n = 26), PP (n = 18) | 14.9 years (9.6) | 45.9 (10.4) | + | + | Nm | Nm |
|
| ||||||||||
| Radomski et al. 2015 [23] | 32 | 20 | Median: 3 (range: 0–6.5) | RR (n = 22), SP (n = 10) | 15.9 years (10.3) | 50.8 (9.5) | − | + | + | + |
|
| ||||||||||
| Kleeberg et al. 2004 [20] | 20 | 16 | Median: 2 (range: 1.5–6.5) | RR (n = 16), SP (n = 4) | Median 103 months (range: 7–300) | Median 38 (25–57) | + | + | + | Nm |
|
| ||||||||||
| Cogo et al. 2014 [17] | 60 | 35 | Mean 1.4 (SD: 1, range: 0–3.5) | RR | 40.8 months (SD 45, range: 2–264) | 34 (7.7) | nm | Nm | ||
|
| ||||||||||
| Simioni 2008 et al. [24] | 109/56 | 50 | MS: Mean 1.82 (SD: 0.4) | RR (n = 109), | 2.8 (1.9) years | 34 (9.3) | + | + | + | + |
| CIS: Mean: 1.66 (SD: 0.4) | CIS (n = 56) | 1.4 (1.3) years | 37.9 (8.3) | + | + | + | + | |||
|
| ||||||||||
| García-Molina et al. 2008 [19] | 18 | 18 | Mean: 6.7 (SD: 0.69) | RR (n = 7); SP (n = 4); PP (n = 7) | 17.14 (6.55) years | 49.33 (7.8) | Nm | Nm | Nm | Nm |
|
| ||||||||||
| Nagy et al. 2006 [22] | 21 | 30 | Mean: 1.7 (range: 0–3) | RR | 3.1 years (1.1) | 32.4 (9.8) | Nm | + | Nm | Nm |
|
| ||||||||||
| Roca et al. 2008 [27] | 12 | 12 | <2 | RR | Mean 29.5 months (SD 12.4, range: 11–36) | 32.5 (7.97) | + | + | Nm | Nm |
|
| ||||||||||
| García-Molina et al. 2009 [16] | 9 | 18 | Mean: 7.2 (SD: 0.3) | PP | 17.3 years (6.1) | 51.4 (4.7) | Nm | Nm | Nm | Nm |
| 10 | 18 | Mean: 7 (SD: 0.5) | SP | 16.6 years (4.8) | 46 (14.1) | Nm | Nm | Nm | Nm | |
|
| ||||||||||
| Azcárraga-Guirola et al. 2016 [28] | 16 | 19 | Range: 2.5–4.5 | RR (n = 9); SP (n = 4); not defined (n = 3) | 8.9 years (7) | 39.4 (12.6) | − | + | Nm | Nm |
Nm: not measured; +: present; −: absent; HC: healthy controls; RR: relapsing remitting; SP: secondary progressive; PP: primary progressive; SD: standard deviation.