Table 4.

Exosomal proteins found in urinary EVs from HIV+ patients.

	Genes in our analysis	Genes in the FunRich database	Percentage of genes	Fold enrichment
Exosomal proteins	1932	2001	29.44	2.11
A1BG, A2M, AARS, ABCA7, ABCB1, ABCB11, ABCB6, ABCC1, ABCC11, ABCC9, ABCG2, ABHD8, ACAA2, ACAT1, ACAT2, ACE, ACE2, ACLY, ACO1, ACOT11, ACP2, ACSL3, ACSL4, ACSM1, ACTA1, ACTA2, ACTB, ACTBL2, ACTC1, ACTG1, ACTL6A, ACTN1, ACTN2, ACTN4, ACTR1A, ACTR1B, ACTR2, ACTR3, ACY1, ACY3, ADAM10, ADAMTS3, ADCY1, ADH5, ADH6, ADK, ADSL, AEBP1, AGAP2, AGR2, AGR3, AGRN, AGT, AHCTF1, AHCYL1, AHNAK, AHSA1, AHSG, AK1, AK2, AKAP9, AKR1A1, AKR1B10, ALAD, ALB, ALCAM, ALDH16A1, ALDH1A1, ALDH1L1, ALDH2, ALDH3B1, ALDH8A1, ALDOA, ALDOB, ALDOC, ALK, ALOX12, ALPL, ALPP, ALYREF, AMBP, AMN, ANGPT1, ANGPTL1, ANGPTL4, ANKFY1, ANKRD11, ANO1, ANO6, ANPEP, ANXA1, ANXA11, ANXA13, ANXA3, ANXA4, ANXA6, ANXA7, AOX1, AP1M1, AP2A1, AP2A2, AP2M1, AP4M1, APAF1, APLP2, APOA1, APOA2, APOB, APOD, APOE, APOL1, APP, APPL1, APPL2, APRT, AQP2, ARF5, ARFIP1, ARHGAP1, ARHGAP23, ARHGDIA, ARHGDIB, ARHGEF12, ARHGEF18, ARL15, ARL3, ARL8B, ARMC3, ARMC9, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC5, ARRDC1, ARSE, ARSF, ARVCF, ASAH1, ASB6, ASL, ASNA1, ASNS, ATAD2, ATIC, ATP1A1, ATP1A2, ATP1A3, ATP2B1, ATP2B2, ATP2B4, ATP4A, ATP5A1, ATP5B, ATP5L, ATP6AP1, ATP6AP2, ATP6V0A1, ATP6V0A4, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V1A, ATP6V1B1, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1H, ATRN, AUP1, AZGP1, AZU1, B2M, B3GAT3, B4GALT1, B4GALT3, BAIAP2, BAIAP2L1, BASP1, BAZ1B, BCAM, BCR, BDH2, BGN, BHLHB9, BHMT, BHMT2, BLMH, BLOC1S5, BLVRA, BLVRB, BMP3, BPI, BPIFB1, BPTF, BRI3BP, BROX, BSG, BTG2, BTN1A1, C11orf52, C11orf54, C16orf80, C16orf89, C17orf80, C19orf18, C1GALT1C1, C1orf116, C1QC, C1QTNF1, C1QTNF3, C1R, C2orf16, C3, C4BPA, C5, C9, CAB39L, CACNA2D1, CACYBP, CAD, CALM1, CALML3, CALR, CAMK4, CAMP, CAND1, CANX, CAP1, CAPN1, CAPN2, CAPN5, CAPN7, CAPNS1, CAPS, CAPZA2, CAPZB, CARD11, CASP9, CAV1, CBR3, CC2D1A, CCDC105, CCDC132, CCL28, CCPG1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CD101, CD14, CD163L1, CD19, CD2, CD22, CD274, CD2AP, CD300A, CD36, CD37, CD40, CD44, CD53, CD55, CD58, CD59, CD63, CD70, CD74, CD79B, CD80, CD81, CD9, CD97, CDC42, CDC42BPA, CDC42BPB, CDH1, CDH17, CDHR2, CDHR5, CDK1, CDK5RAP2, CDKL1, CEACAM5, CELSR2, CEMIP, CEP250, CES2, CETP, CFD, CFH, CFI, CFL1, CHGB, CHID1, CHMP1A, CHMP2B, CHMP4B, CHRDL2, CHST1, CHST14, CIB1, CKAP4, CKB, CLASP1, CLCA4, CLDN3, CLDN4, CLDN7, CLIC1, CLIC4, CLIC5, CLIC6, CLIP2, CLSTN1, CLTC, CLTCL1, CLU, CMPK1, CNDP2, CNKSR2, CNTLN, COASY, COBLL1, COL12A1, COL15A1, COL18A1, COL6A1, COL6A2, COL6A3, COLEC10, COLGALT1, COMT, COPA, COPB1, COPB2, COPS8, CORO1A, CORO1B, COX4I1, COX5B, CP, CPD, CPN2, CPNE1, CPNE3, CPNE5, CPNE8, CPVL, CR1, CR2, CRB2, CREB5, CRISPLD1, CRNN, CRTC2, CRYAB, CRYZ, CS, CSE1L, CSK, CSPG4, CSRP1, CST4, CSTB, CTDSPL, CTNNA1, CTNNB1, CTNND1, CTSB, CTSC, CTSG, CTTN, CUBN, CUL3, CUL4B, CUTA, CUX2, CXCR4, CYB5R1, CYBRD1, CYFIP1, CYFIP2, CYP2J2, DAAM2, DAG1, DAK, DARS, DBNL, DCD, DCTN2, DCXR, DDAH1, DDAH2, DDB1, DDC, DDR1, DDX11, DDX19A, DDX19B, DDX21, DDX23, DDX3X, DDX5, DERA, DHCR7, DHX34, DHX36, DHX9, DIAPH2, DIP2A, DIP2B, DIP2C, DLD, DLG1, DMBT1, DNAH7, DNAH8, DNAJA1, DNAJA2, DNAJB1, DNAJB9, DNAJC13, DNAJC3, DNAJC7, DNHD1, DNM2, DNPH1, DOCK10, DOCK2, DOPEY2, DPEP1, DPP3, DPP4, DPYS, DPYSL2, DSC2, DSG2, DSG3, DSP, DSTN, DUOX2, DUSP26, DUT, DYNC1H1, DYNC2H1, DYSF, ECE1, ECH1, ECM1, EDIL3, EEA1, EEF1A1, EEF1A2, EEF1D, EEF1G, EEF2, EFEMP1, EFEMP2, EGF, EGFR, EHD1, EHD2, EHD3, EHD4, EIF2S1, EIF2S3, EIF3A, EIF3B, EIF3E, EIF3L, EIF4A1, EIF4A2, EIF4A3, EIF4E, EIF4G1, EIF4H, ELANE, EML5, ENO1, ENO2, ENO3, ENPP3, ENPP4, ENPP6, ENTPD1, EPB41L2, EPCAM, EPHA2, EPHA5, EPHB1, EPHB2, EPHB3, EPHB4, EPHX2, EPN3, EPPK1, EPRS, EPS8, EPS8L1, EPS8L2, EPS8L3, ERAP1, ERBB2, ERMN, ERO1L, ERP44, ESD, ETFA, EVPL, EXOC4, EXOSC10, EXT2, EYS, EZR, F11, F11R, F5, F7, FABP1, FABP3, FAH, FAM129A, FAM129B, FAM151A, FAM208B, FAM209A, FAM20A, FAM20C, FAM49B, FAM65A, FAS, FASLG, FASN, FAT1, FAT2, FBL, FBP1, FBP2, FCGBP, FCN1, FCN2, FERMT3, FGA, FGB, FGG, FGL2, FGR, FH, FIGNL1, FKBP1A, FKBP4, FKBP5, FLNA, FLNB, FLNC, FLOT1, FLOT2, FMNL1, FN1, FOLH1, FRK, FSCN1, FTCD, FUCA1, FURIN, FUS, FUT2, FUT3, FUT6, FUT8, FUZ, G6PD, GAA, GABRB2, GAL3ST4, GALK1, GALM, GALNT3, GANAB, GARS, GART, GATSL3, GBE1, GBP6, GCN1L1, GCNT2, GCNT3, GDF2, GDI2, GDPD3, GEMIN4, GFPT1, GGCT, GGH, GGT1, GHITM, GIPC1, GK, GK2, GLB1, GLDC, GLG1, GLIPR2, GLO1, GLUD1, GLUL, GNA13, GNAI1, GNAI2, GNAQ, GNAS, GNB1, GNB2, GNB2L1, GNB3, GNB4, GNB5, GNG12, GNPDA1, GNPTG, GOLGA4, GOLGA7, GOT1, GOT2, GPC1, GPC4, GPD1, GPI, GPM6A, GPR155, GPR64, GPR98, GPRASP1, GPRC5A, GPRC5B, GPT, GREB1, GRHPR, GRID1, GRIN1, GRK4, GSN, GSR, GSS, GSTA3, GSTCD, GSTK1, GSTO1, GSTP1, GUSB, H1FOO, H2AFY, H2AFY2, HADHA, HAPLN3, HAUS5, HBB, HBD, HBS1L, HDHD2, HEBP1, HEBP2, HEPH, HGD, HGS, HINT1, HIRA, HIST1H1B, HIST1H2BA, HIST1H2BL, HIST2H2AC, HLA-A, HLA-B, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DRB5, HLAE, HNMT, HNRNPA1, HNRNPA2B1, HNRNPC, HNRNPF, HNRNPK, HNRNPL, HP, HPD, HPGD, HPR, HPRT1, HRG, HRNR, HSD17B10, HSD17B4, HSP90AB1, HSP90B1, HSPA12A, HSPA13, HSPA1L, HSPA2, HSPA4, HSPA5, HSPA6, HSPA8, HSPA9, HSPB1, HSPB8, HSPD1, HSPG2, HSPH1, HTATIP2, HTRA1, HUWE1, HYOU1, IARS, ICAM1, ICAM3, IDH1, IFITM2, IFITM3, IGF2R, IGFALS, IGSF3, IGSF8, IKZF5, IMPDH2, INADL, INSR, IQCB1, IQCG, IQGAP1, IQGAP2, IRF6, IST1, ITFG3, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA6, ITGAL, ITGAV, ITGB1, ITGB2, ITGB3, ITGB4, ITGB7, ITGB8, ITIH2, ITIH4, ITM2C, ITSN1, ITSN2, IVL, JADE2, JUP, KALRN, KCNG2, KHK, KIAA1324, KIF12, KIF15, KIF18B, KIF3A, KIF3B, KIF9, KIFC3, KL, KNG1, KPNB1, KPRP, KRT1, KRT10, KRT12, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT24, KRT25, KRT27, KRT28, KRT3, KRT5, KRT6C, KRT7, KRT73, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT9, L1CAM, LAD1, LAMA3, LAMA4, LAMA5, LAMB2, LAMB3, LAMC1, LAMC2, LAMP1, LAMP2, LAMTOR3, LBP, LCK, LCP1, LDHA, LDHB, LEPRE1, LFNG, LGALS3, LGALS3BP, LGALS4, LIMA1, LIN7A, LIN7C, LMAN1, LMAN2, LOXL4, LPO, LRP1, LRP1B, LRP2, LRP4, LRPPRC, LRRC15, LRRC16A, LRRC57, LRRK2, LRSAM1, LSP1, LSR, LTA4H, LTBP3, LTF, LUZP1, LYPLA2, MAGI3, MAL2, MAN1A1, MAN1A2, MAN2A1, MAP4K4, MAP7, MARCKSL1, MARK3, MARS, MARVELD2, MASP1, MASP2, MBD5, MBLAC2, MCAM, MCPH1, MDH1, MDH2, MEGF8, MEP1A, MEST, METRNL, MFGE8, MFI2, MGAM, MGAT1, MGAT4A, MID2, MIF, MINK1, MLLT3, MLLT4, MME, MMP24, MMP25, MMRN1, MMRN2, MNDA, MOB1A, MOB1B, MOGS, MPO, MPP5, MPP6, MS4A1, MSH6, MSN, MSRA, MTA1, MTAP, MTCH2, MTHFD1, MTMR11, MTMR2, MUC13, MUC16, MUC4, MUM1L1, MVB12A, MVB12B, MVP, MX1, MXRA5, MXRA8, MYADM, MYH10, MYH11, MYH13, MYH14, MYH3, MYH8, MYH9, MYL6B, MYO15A, MYO1B, MYO1C, MYO1D, MYO1E, MYO1G, MYO5B, MYO6, MYOF, N4BP2L2, NAA16, NAA50, NACA, NAGLU, NAMPT, NAP1L4, NAPA, NAPG, NAPRT, NAPSA, NARS, NBR1, NCALD, NCCRP1, NCKAP1, NCKAP1L, NCL, NCOA3, NCSTN, NDRG1, NDRG2, NEB, NEBL, NEDD4, NEDD4L, NEDD8, NEU1, NID1, NIN, NIPBL, NIT2, NKX61, NONO, NOTCH1, NOX3, NPC1, NPEPPS, NPHS1, NPHS2, NPM1, NPNT, NQO2, NT5C, NT5E, NUCB1, NUCB2, NUDT5, NUMA1, NXPE4, OLA1, OPTN, OR2A4, OS9, OSBPL1A, OXSR1, P2RX4, P4HB, PA2G4, PACSIN2, PACSIN3, PADI2, PAFAH1B1, PAFAH1B2, PAGE2, PAICS, PAM, PARD6B, PARP4, PBLD, PCBP1, PCDHGB5, PCK1, PCLO, PCNA, PCSK9, PCYOX1, PDCD2, PDCD5, PDCD6, PDCD6IP, PDDC1, PDE8A, PDIA2, PDIA3, PDIA4, PDIA6, PDLIM7, PDZK1, PEBP1, PECAM1, PEF1, PEPD, PEX1, PFAS, PFKL, PFKP, PGAM1, PGD, PGK1, PGLYRP1, PGM1, PHB2, PHGDH, PI4KA, PIGR, PIK3C2A, PIK3C2B, PILRA, PIP, PIP4K2C, PKD1, PKD1L3, PKD2, PKHD1, PKLR, PKM, PKN2, PKP3, PLAT, PLAU, PLCB1, PLCD1, PLCG2, PLD3, PLEC, PLEKHA1, PLEKHA7, PLEKHB2, PLG, PLIN2, PLOD1, PLOD2, PLOD3, PLS1, PLSCR1, PLTP, PLVAP, PLXNA1, PLXNB2, PM20D1, PMEL, PNP, PODXL, POFUT2, PON1, PON3, POTEE, POTEF, POTEI, POTEM, PPA1, PPARG, PPFIA2, PPIA, PPIB, PPL, PPM1L, PPP1CB, PPP1R7, PPP2CA, PPP2R1A, PPP2R1B, PRCP, PRDX1, PRDX3, PRDX4, PRDX5, PRG4, PRKAR2A, PRKCA, PRKCD, PRKCH, PRKCI, PRKCZ, PRKDC, PRKRIP1, PRNP, PROM1, PROM2, PROS1, PROZ, PRRC2A, PRSS23, PRTN3, PSAP, PSAT1, PSMA2, PSMA3, PSMA5, PSMA7, PSMB1, PSMB3, PSMB4, PSMB5, PSMB6, PSMB8, PSMB9, PSMC2, PSMC4, PSMC6, PSMD11, PSMD12, PSMD13, PSMD2, PSME1, PSME2, PSME3, PTBP1, PTER, PTGFRN, PTGR1, PTGS1, PTPN13, PTPN23, PTPRA, PTPRC, PTPRF, PTPRJ, PTPRO, PTRF, PTX3, PYGB, PYGL, QDPR, QPCT, QPRT, QSOX1, RAB10, RAB11B, RAB17, RAB1A, RAB1B, RAB22A, RAB25, RAB29, RAB2A, RAB34, RAB3B, RAB3GAP1, RAB43, RAB4B, RAB6B, RAB7A, RAB8A, RAB8B, RAB9A, RAC1, RACGAP1, RALA, RALB, RAP1A, RAP1B, RAP1GDS1, RAP2A, RAPGEF3, RARRES1, RARS, RASAL3, RASSF9, RBL2, RCC2, REG4, RELN, RENBP, RFC1, RFTN1, RHEB, RHOB, RHOF, RIMS2, RLF, RNASE7, RNF213, RNH1, RNPEP, ROBO2, ROCK2, RP2, RPL10, RPL10A, RPL14, RPL15, RPL23, RPL3, RPL30, RPL34, RPL35A, RPL4, RPL5, RPL6, RPL8, RPLP2, RPN1, RPS11, RPS14, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS27A, RPS3A, RPS4X, RPS4Y1, RPS4Y2, RPS7, RPS9, RRAS, RREB1, RSU1, RTN4, RUSC2, RUVBL1, RUVBL2, RYR1, S100A11, S100A6, S100P, SAA1, SAFB2, SAMM50, SARS, SBSN, SCAMP2, SCAMP3, SCARB1, SCARB2, SCEL, SCIN, SCN10A, SCN11A, SCPEP1, SCRIB, SCRN2, SDCBP, SDF4, SEC31A, SELENBP1, SELP, SEMA3G, SEPP1, SERBP1, SERINC1, SERINC2, SERINC5, SERPINA1, SERPINA3, SERPINA4, SERPINA5, SERPINA7, SERPINB1, SERPINB13, SERPINB6, SERPINB9, SERPING1, SETD4, SFI1, SFN, SFRP1, SFT2D2, SH3BP4, SHMT1, SHMT2, SHROOM2, SIAE, SIRPA, SIT1, SLAMF1, SLAMF6, SLC12A1, SLC12A2, SLC12A3, SLC12A7, SLC12A9, SLC13A2, SLC13A3, SLC15A2, SLC16A1, SLC1A1, SLC1A4, SLC1A5, SLC20A2, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A5, SLC22A6, SLC23A1, SLC25A1, SLC25A3, SLC25A4, SLC25A6, SLC26A11, SLC26A4, SLC26A9, SLC27A2, SLC29A1, SLC2A1, SLC2A3, SLC34A2, SLC35D1, SLC36A2, SLC37A2, SLC38A1, SLC39A5, SLC3A1, SLC3A2, SLC44A1, SLC44A2, SLC44A4, SLC46A3, SLC4A1, SLC4A4, SLC5A1, SLC5A10, SLC5A2, SLC5A5, SLC5A6, SLC5A8, SLC5A9, SLC6A13, SLC6A14, SLC6A19, SLC7A5, SLC9A1, SLC9A3, SLC9A3R1, SLC9A3R2, SLCO4C1, SLIT2, SLK, SMC2, SMC3, SMIM22, SMIM24, SMO, SMPDL3B, SMURF1, SNCG, SND1, SNRNP200, SNX12, SNX18, SNX25, SNX33, SNX9, SOD1, SOGA1, SORD, SORL1, SORT1, SPAG9, SPAST, SPEN, SPINK1, SPON2, SPRR3, SPTAN1, SPTBN1, SQSTM1, SRC, SRPR, SRSF7, ST13, ST3GAL1, ST3GAL6, STAMBP, STAU1, STIP1, STK10, STK11, STK24, STOM, STRIP1, STX3, STX4, STX7, STXBP1, STXBP2, STXBP3, STXBP4, SUB1, SUCLA2, SUSD2, SYAP1, SYNE1, SYNE2, TAB3, TACSTD2, TAF6L, TALDO1, TAOK1, TARS, TAX1BP1, TAX1BP3, TBC1D10A, TBC1D21, TC2N, TCP1, TECTA, TEKT3, TEX14, TF, TFRC, TGFB1, TGFBI, TGFBR3, TGM1, TGM2, TGM3, TGM4, THBS1, THBS2, THRAP3, THSD4, THY1, TIAM2, TINAGL1, TJP2, TKT, TLN1, TLR2, TM7SF3, TM9SF2, TMBIM1, TMC6, TMC8, TMED2, TMED9, TMEM109, TMEM192, TMEM2, TMEM256, TMEM27, TMEM63A, TMPRSS11B, TMPRSS11D, TMPRSS2, TNFAIP3, TNFRSF8, TNFSF10, TNFSF13, TNIK, TNKS1BP1, TNPO3, TOLLIP, TOM1, TOM1L2, TOMM70A, TOR1A, TOR1B, TOR3A, TPI1, TPM3, TPP1, TPRG1L, TRAP1, TREH, TRIP10, TSNAXIP1, TSPAN1, TSPAN15, TSPAN3, TSSK3, TSTA3, TTC17, TTC18, TTLL3, TTN, TTR, TUBA1B, TUBA4A, TUBB3, TUBB4A, TUBB8, TUFM, TWF2, TXNDC16, TXNDC8, TXNRD1, TYK2, TYRP1, UACA, UBA1, UBAC1, UBASH3A, UBE2N, UBE2V2, UBL3, UBXN6, UEVLD, UGDH, UGGT1, UGP2, ULK3, UMOD, UPB1, UPK1A, UPK3A, UQCRC2, UTRN, UXS1, VAMP1, VAMP3, VAMP7, VAPA, VASN, VASP, VAT1, VCL, VCP, VDAC3, VIL1, VIM, VMO1, VPS13C, VPS13D, VPS28, VPS35, VPS36, VPS37B, VPS37C, VPS37D, VPS4A, VPS4B, VTA1, VWA2, VWF, WARS, WAS, WASF2, WASL, WDR1, WIZ, WNT5B, XDH, XPNPEP2, XPO1, XRCC5, XRCC6, YBX1, YES1, YWHAE, YWHAG, YWHAH, YWHAZ, ZCCHC11, ZDHHC1, ZFYVE20, ZG16B, ZMPSTE24, ZNF114, ZNF486, ZNF571, and ZNHIT6.

GENE: ExoCarta (http://exocarta.org/exosome_markers_new) [33]; GENE: EV antibody array [35]; GENE: HIV exosomal proteins [36].