Table 7.

Comparison of pathways between HIV+ groups from Pathway Studio 11.4.

HIV group	Pathway
CD4+ T cells greater than 300 n = 15	Natural killer cell inhibitor receptor signaling Intermediate filament polymerization Ca2+ flux regulation G1/S phase transition G2/M phase transition S/G2 phase transition Protein folding Golgi to endosome transport Endosomal recycling Kinetochore assembly
CD4+ T cells less than 300 n = 15	Neutrophil chemotaxis Vascular motility Platelet activation via GPCR signaling Insulin influence on protein synthesis mTOR signaling overview EDNRA/B → vascular motility Proplatelet maturation Natural killer cell activation through ITAM-containing receptors Taste sensor receptors activates mTOR signaling Natural killer cell activation
Low VLs n = 14	Intermediate filament polymerization Natural killer cell inhibitory receptor signaling golgi to endosome transport Ca+ flux regulation HRH1/3 → synaptic transmission Vascular motility Endosomal recycling G1/S phase transition Golgi transport G2/M phase transition
High VLs n = 10	Metaphase/anaphase phase transition S/G2 phase transition Spindle assembly Natural killer cell activation Histone ubiquitylation Eosinophil survival by cytokine signaling Protein folding G2/M phase transition