Table 8.
Functional enrichment analysis of control EV proteins.
| Genes in the database | Genes in the Bkg. database | Percentage of genes | Fold enrichment | Corrected P value (BH FDR ) | |
|---|---|---|---|---|---|
| Site of expression | |||||
| Cervicovaginal fluid | 16 | 544 | 12.0 | 4.2 | 2.59E − 06 |
| Neutrophils | 13 | 392 | 9.7 | 4.8 | 6.68E − 06 |
| Gastric juice | 9 | 222 | 6.7 | 6.1 | 4E − 05 |
| Molecular function | |||||
| Defense/immunity protein activity | 5 | 52 | 3.7 | 15.7 | 3.96E − 05 |
| Biological process | |||||
| Immune response | 13 | 561 | 9.8 | 3.4 | 0.00026 |
| Signal transduction | 43 | 3907 | 32.5 | 1.5 | 0.0026 |
| Cell communication | 41 | 3687 | 31.1 | 1.5 | 0.0028 |
| Antigen presentation | 1 | 1 | 0.7 | 134.4 | 0.0073 |