Table 3.

Biomarker candidates under study.

Functional MRI measures of regional activation

Magnitude of activation (beta contrast estimates) in iM1, cM1, iPMd, and cPMd

Volume of activation in iM1, cM1, iPMd, and cPMd

Measures of functional connectivity

Functional connectivity between iM1 and cM1

Functional connectivity between iM1 and cPMd

Functional connectivity between iM1 and iPMd

DTI measure of white matter integrity within corticospinal tract

Fractional anisotropy within ipsilesional cerebral peduncle

Peri-infarct angiogenesis

T2∗-weighted signal in infarct Rims of two different diameters

M1: primary motor cortex; PMd: dorsal premotor cortex; i: ipsilesional; c: contralesional.