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The comparison of fluostatin biosynthetic gene clusters and the proposed biosynthetic pathways of compounds 1–5. (A) The comparison of fluo gene clusters from Streptomyces sp. PKU-MA00045 with other fluostatin biosynthetic gene clusters. The homologous genes between fluo and fls gene clusters were linked with lines. (B) The proposed biosynthetic pathways of compounds 1–5. The protein homologues from the fls pathway are shown in parentheses.
