Table 3.
Inhibitory effects of compounds 1–3 on superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils at 10 μM.
| Compound | Superoxide Anion Generation | Elastase Release | ||||
|---|---|---|---|---|---|---|
| IC50 (μM) a | Inh% b | IC50 (μM) a | Inh% b | |||
| 1 | 7.1 ± 0.3 | 63.1 ± 1.1 | *** | 4.5 ± 0.9 | 91.7 ± 3.1 | *** |
| 2 | >10 | 14.7 ± 5.7 | >10 | 31.8 ± 5.0 | ** | |
| 3 | >10 | 17.8 ± 2.8 | ** | 0.9 ± 0.1 | 95.4 ± 3.6 | *** |
| Idelalisib | 0.07 ± 0.01 | 102.8 ± 2.2 | *** | 0.3 ± 0.1 | 99.6 ± 4.2 | *** |
a Concentration necessary for 50% inhibition (IC50); b percentage of inhibition (Inh%) at a 10 μM concentration. Results are presented as the mean ± S.E.M. (n = 3–4). ** p < 0.01, *** p < 0.001 compared with the control value.