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Aging and excess ω-6 drives the proinflammatory milieu with increased 15-lipoxygenase (LOX) expression in the left ventricle (LV). A and B: mRNA expression of IL-1β, TNF-α, and IL-6 (A) and arachidonate lipoxygenase (Alox)-12, Alox-15, and Alox-5 (B) in the LV. C: immunoblot analysis and densitometry of 5-LOX in the LV. Values are means ± SE; n = 4 mice/group. *P < 0.05 vs. the young-laboratory chow (LC) group; $P < 0.05, LC vs. safflower oil (SO).
