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Exscien1-III reduced mitochondrial apoptotic markers. A: mRNA levels of p53 in ventricular homogenates from mice treated with Exscien1-III or vehicle (Veh). B−D: protein expression of Bax (B), cleaved caspase-3 (C), and cleaved caspase-9 (D) in cardiac mitochondrial fractions from mice treated with Exscien1-III or Veh at 12 wk after transverse aortic constriction (TAC). Circles inside bars denote n values per group. COX IV, cytochrome c oxidase subunit IV.
