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. 2017 Oct 18;314(2):R313–R321. doi: 10.1152/ajpregu.00321.2017

Fig. 2.

Fig. 2.

Central serotonin (5-hydroxytryptamine, 5-HT) deficiency leads to reduced blood pressure in quiet sleep (QS), and reduced heart rate (HR) in both sleep states. Shown are mean arterial pressure (MAP; A), systolic blood pressure (sBP; B), diastolic blood pressure (dBP; C), and HR (D) for 5-HT-deficient (TPH2−/−) rat pups (solid bars; n = 34 male, 35 female) and wild-type (WT) littermates (open bars; n = 38 male, 31 female) in QS; left) and AS; right). *Significant effect of genotype [2-factor ANOVA (2FA); P < 0.01 for all variables]; †significant interaction between genotype and sleep state, testing data from animals displaying both QS and AS [3-factor, repeated-measures ANOVA (3FRMA; P < 0.001 for all variables]. For this and subsequent figures, data are mean values ± SE.