Table 1.
Sleep architecture of group 1 WT and TPH2−/− pups
| QS |
AS |
|||||||
|---|---|---|---|---|---|---|---|---|
| Genotype | Sex | W (%Time) | No. of episodes | Episode duration, s | %Time | No. of episodes | Episode duration, s | %Time |
| WT | ♂ n = 12 | 58.0 ± 3.8 | 90.3 ± 13.0 | 39.9 ± 4.1 | 34.8 ± 3.2 | 7.5 ± 2.3 | 66.7 ± 7.6 | 7.2 ± 2.4 |
| ♀ n = 11 | 53.5 ± 3.6 | 64.8 ± 9.5 | 46.1 ± 4.0 | 36 ± 1.9 | 9.4 ± 2.2 | 82.3 ± 8.7 | 10.5 ± 3.1 | |
| TPH2−/− | ♂ n = 11 | 67.9 ± 5.8† | 38.6 ± 5.5* | 52.4 ± 9.2 | 26.9 ± 4.9† | 3.6 ± 1.6* | 92.6 ± 26 | 5.3 ± 2.2† |
| ♀ n = 12 | 67.5 ± 3.1† | 42.7 ± 5.0* | 55.3 ± 9.8 | 26.3 ± 2.7† | 5.1 ± 1.1* | 103.1 ± 8.6 | 6.3 ± 1.2† | |
Values are means ± SE; n, number of pups. Shown are variables for periods of wakefulness (W), quiet sleep (QS), and active sleep (AS). WT, wild type; TPH2−/−, serotonin (5-hydroxytryptamine, 5-HT) deficient.
*
Significant effect of genotype, indicating that TPH2−/− pups have fewer episodes of QS and AS.
†
Significant genotype × state interaction, indicating that TPH2−/− spend more time in W, and less time in QS and AS, vs. WT. Significance at P < 0.05.