Table 2.
Baseline MAP and HR for group 1 WT and TPH2−/− pups
| QS |
AS |
||||
|---|---|---|---|---|---|
| Genotype | Sex | MAP, mmHg | HR, beats/min | MAP, mmHg | HR, beats/min |
| WT | ♂ n = 12 | 54.1 ± 0.7† | 478 ± 5 | 51.3 ± 0.8 | 465 ± 6 |
| ♀ n = 11 | 52.4 ± 0.9† | 474 ± 7 | 50.3 ± 0.8 | 466 ± 5 | |
| TPH2−/− | ♂ n = 11 | 47.6 ± 1.1 | 393 ± 13* | 50.0 ± 1.3 | 406 ± 16* |
| ♀ n = 12 | 49.3 ± 0.9 | 413 ± 11* | 51.3 ± 0.9 | 411 ± 15* | |
Values are means ± SE; n, number of pups. Shown are variables during periods of quiet sleep (QS) and active sleep (AS). MAP, mean arterial pressure; HR, heart rate; WT, wild-type.
*
Significant effect of genotype, indicating lower HR in TPH2−/− pups in both states.
†
Significant genotype × state interaction, indicating that the MAP of WT pups is elevated in QS vs. AS, an effect absent in TPH2−/− pups. Significance at P < 0.05.