Table 4.
Proportions of dead and mean survival times in 207 patients with West syndrome. Hazard ratios from Cox regression models, calculated for symptomatic versus cryptogenic etiology, male versus female sex, and not treated versus treated with ACTH
| Characteristic | Total | Dead | Median survival time, years | Cox regression | ||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariate | |||||||
| N | N (%) | Med | 95% CI | HR | 95% CI | HR | 95% CI | |
| All | 207 | 102 (49) | 48.6 | 38.5–NA | – | – | – | – |
| Etiologya | ||||||||
| Symptomatic | 181 | 98 (54) | 40.4 | 31.3–51.5 | 4.7 | 1.8–12.9 | 4.6 | 1.7–12.6 |
| Cryptogenic | 26 | 4 (15) | NA | 50.6–NA | ||||
| Sex | ||||||||
| Male | 126 | 65 (52) | 43.2 | 30.3–NA | 1.2 | 0.8–1.8 | 1.2 | 0.8–1.8 |
| Female | 81 | 37 (46) | 50.6 | 38.8–NA | ||||
| ACTH treatment | ||||||||
| No | 46 | 28 (61) | 27.7 | 16.8–50.4 | 1.5 | 1.0–2.3 | 1.4 | 0.9–2.2 |
| Yes | 161 | 74 (46) | 50.6 | 40.3–NA | ||||
ACTH, adrenocorticotropic hormone; CI, confidence interval; HR, hazard ratio; Med, median.
a
p = 0.002 in univariate analysis, and p = 0.003 in multivariate analysis.