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The replication of mitochondrial DNA (mtDNA) in vertebrates is primed via processed mRNA molecules [22,23]. We propose that a product inhibition exists that diminishes transcription (−), and thus replication, if sufficient proteins are available. If a deletion event eliminates the genes for proteins that participate in this feedback, transcription and also replication will not be downregulated in such mutants, resulting in a replication advantage (+).
