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. 2018 Mar 13;9(3):159. doi: 10.3390/genes9030159

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of the effects of CD99 silencing in Ewing sarcoma cells. The abrogation of CD99 induces Ewing sarcoma neural differentiation through nuclear ERK1/2 stabilization and miR34a upregulation and Notch-NF-kB inhibition [59,74].