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. 2018 Mar 19;9:513. doi: 10.3389/fimmu.2018.00513

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Copyright © 2018 Dey, Allen, Fraser, Snyder, Tian, Zhang, Paulson, Patterson, Cantorna and Hankey-Giblin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Loss of Ron stimulates exacerbated neuroinflammation following diet-induced obesity. (A) Weight of wild-type (WT) and Ron^−/− mice maintained on a HFD for 18 (n = 16 mice/genotype) and/or 27 weeks (n = 16 mice/genotype). (B–D) WT and Ron^−/− mice were maintained on a HFD for 18 or 27 weeks and expression of M1 genes, M2-gene Arg-1, Ly6C, and matrix metalloproteinases (MMPs) in the central nervous system (CNS) was assessed by qPCR (n = 6 mice/genotype). (E,F) Total CNS immune cells were isolated from the CNS of WT and Ron^−/− mice maintained on a HFD for 18 or 27 weeks and numbers of CD45⁺F480⁺Ly6C⁺ infiltrating macrophages was assessed by flow cytometry (n = 8 mice/genotype) (*P < 0.05, **P < 0.01, ***P < 0.001).

Loss of Ron stimulates exacerbated neuroinflammation following diet-induced obesity. (A) Weight of wild-type (WT) and Ron^−/− mice maintained on a HFD for 18 (n = 16 mice/genotype) and/or 27 weeks (n = 16 mice/genotype). (B–D) WT and Ron^−/− mice were maintained on a HFD for 18 or 27 weeks and expression of M1 genes, M2-gene Arg-1, Ly6C, and matrix metalloproteinases (MMPs) in the central nervous system (CNS) was assessed by qPCR (n = 6 mice/genotype). (E,F) Total CNS immune cells were isolated from the CNS of WT and Ron^−/− mice maintained on a HFD for 18 or 27 weeks and numbers of CD45⁺F480⁺Ly6C⁺ infiltrating macrophages was assessed by flow cytometry (n = 8 mice/genotype) (*P < 0.05, **P < 0.01, ***P < 0.001).