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. 2017 Sep 27;26(24):4896–4905. doi: 10.1093/hmg/ddx370

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Salubrinal enhances photoreceptor survival in P23H-1 rats. P23H-1 rats were treated from P21-P35 with either 1 mg/kg salubrinal or vehicle. (A) Representative western blot of retina lysates of P23H-1 rats treated with salubrinal or vehicle for p-eIF2α, eIF2α, ATF4, and CHOP. β-tubulin was used as a loading control. (B) Quantification of expression levels of p-eIF2α, total eIF2α, PERK ATF4 and CHOP relative to vehicle. (C, D) Scotopic ERG a-wave (C) and b-wave (D) amplitude results of P23H-1 rats (P36) treated from P21-P35 with either salubrinal (n = 8) or vehicle (n = 9). (E) Spider plot showing P23H-1 ONL thickness at P36 after salubrinal (n = 5) or vehicle (n = 4) assessed by OCT. (F) Mean ONL thickness across the whole retina Values are mean ± SEM, **P < 0.01, Student’s t-test.