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. 2017 Sep 27;26(24):4896–4905. doi: 10.1093/hmg/ddx370

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — PERK inhibition increases rhodopsin ER localisation in P23H-1 rats. P23H-1 rats were treated from P21-P35 with either (A, B) 100 mg/kg or (C, D) 10 mg/kg PERKi or vehicle. (A, C) Immunohistochemistry of rhodopsin (green) and BiP (red) immunoreactivity in the ONL and inner segment (IS). Scale bar 10 µm. (B, D) Rhodopsin-BiP co-localisation quantified by calculating the Pearson's and Mander's co-localisation coefficients using the JaCOP plug-in and ImageJ software, n = 18 images each from 3 vehicle-treated mice and 3 PERKi-treated mice. Values are means ± SEM, *P < 0.05, ***P < 0.001, unpaired two-sided Student's t test.