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. 2018 Mar 19;12:173. doi: 10.3389/fnins.2018.00173

Figure 3.

Figure 3

Effects of lead, DSP-4 and L-DOPA treatment on exploratory locomotor activity. Exploratory activity histograms represent the number of horizontal movements recorded during the first session of 5 min in the “open field” before and during lead treatment (A). (B) The number of horizontal movements recorded during 5 min on day 56 of lead treatment was compared with the exploratory activity of DSP-4 treated animals. (C) Histograms showing the effect of L-DOPA treatment in lead and DSP-4 rats. Values are the mean ± SEM. Data from controls (n = 12) and lead rats (n = 12) on (A) were compared using the two-way ANOVA followed by Sidak's post-hoc test. Data from controls, lead and DSP-4 rats (n = 12) on (B) were compared using the one-way ANOVA followed by Tukey's post-hoc test. Data from lead and DSP-4 rats before and after L-DOPA treatment on (C) were compared using the Mann Whitney test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, NS no significant.