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. 2018 Mar 19;12:173. doi: 10.3389/fnins.2018.00173

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Copyright © 2018 Sabbar, Delaville, De Deurwaerdère, Lakhdar-Ghazal and Benazzouz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of lead, DSP-4 and L-DOPA treatment on motor coordination assessed by the rotarod test. (A) Motor coordination histograms represent the time spent on the rotarod bar in control and lead treated rats. (B) Histograms showing the comparison of the time spent on the rotarod bar in control, lead and DSP-4 rats on day 56. (C) Histograms showing the effect of L-DOPA in lead and DSP-4 rats. Values are the mean ± SEM. Data from controls and lead rats on (A) were compared using the two-way ANOVA followed by Sidak's post-hoc test. Data from controls (n = 6), lead (n = 6), and DSP-4 rats (n = 6) on (B) were compared using the one-way ANOVA followed by Tukey's post-hoc test. Data from lead (n = 6) and DSP-4 (n = 6) rats on (C) were compared using the Mann whitney test. *P < 0.05, **P < 0.01, ***P < 0.001, NS, no significant.