Skip to main content
. 2018 Feb 27;9(6):929–940. doi: 10.7150/jca.23042

Figure 1.

Figure 1

Expression of CXCR4 and CXCR7 in FTC. (A) Representative tissue samples of FTC, distant metastasis, follicular adenoma and non-neoplastic thyroid tissue, immunohistochemically stained for CXCR4 and CXCR7. All samples were classified as strong expression of the given marker. The bar in the top left corner indicates 50 μm. (B/C) Boxplots display the expression levels of CXCR4 and CXCR7 in non-neoplastic thyroid tissue specimens, follicular adenomas as well as FTC and distant metastases according to the IRS. Boxplots illustrate the median IRS with the upper and lower quartile, as well as maximum and minimum of the given marker. Expression levels of CXCR4 and CXCR7 in the different tissue specimens were compared between groups using the Wilcoxon matched-pairs signed rank test and the non-parametric Mann-Whitney U test as indicated. Bars mark the respective pairs. IRS: immunoreactivity score; CXCR4/7: C-X-C chemokine receptor type 4/7; NT: non-neoplastic thyroid gland; FTC: follicular thyroid carcinoma; DM: distant metastases; *p<0.05; **p<0.01; ***p<0.001.