Table 2.
Correlation between CXCR4 or CXCR7 and clinicopathological parameters in FTC
| Variables | CXCR4 expression | CXCR7 expression | ||||||
|---|---|---|---|---|---|---|---|---|
| Low, n = 18 (%) | High, n = 24 (%) | p-value | Low, n = 15 (%) | High, n = 25 (%) | p-value | |||
| Age, mean±s.d. | 52.6 ± 17.3 | 58.9 ± 16.9 | 0.756 | 56.2 ± 18.9 | 55.8 ± 15.4 | 1 | ||
| Gender | ||||||||
| Male | 5 (28) | 13 (54) | 3 (20) | 12 (40) | ||||
| Female | 13 (72) | 11(46) | 0.120 | 12 (80) | 13 (60) | 0.101 | ||
| Tumour stage | ||||||||
| T1/2 | 14 (28) | 9 (38) | 12 (20) | 10 (40) | ||||
| T3/4 | 4 (72) | 15 (62) | 0.013 | 3 (80) | 15 (60) | 0.022 | ||
| Lymph node metastasis | ||||||||
| N0 | 17 (94) | 22 (92) | 14 (93) | 23 (92) | ||||
| N1a/b | 1 (6) | 2 (8) | 1 | 1 (7) | 2 (8) | 1 | ||
| Distant metastasis | ||||||||
| M0 | 16 (89) | 20 (83) | 13 (87) | 21 (84) | ||||
| M1 | 2 (11) | 4 (17) | 0.685 | 2 (3) | 4 (16) | 1 | ||
| UICC stage | ||||||||
| UICC I/II | 13 (72) | 8 (33) | 11 (73) | 9 (36) | ||||
| UICC III/IV | 5 (28) | 16 (67) | 0.0278 | 4 (27) | 16 (64) | 0.0484 | ||
| Invasiveness | ||||||||
| minimally | 11 (61) | 9 (38) | 10 (67) | 10 (40) | ||||
| widely | 7 (39) | 15 (62) | 0.212 | 5 (33) | 15 (60) | 0.191 | ||
| Low, n 10 = (%) | High, n = 15 (%) | p- value | Low, n = 8 (%) | High, n = 16 (%) | p-value | |||
| Relapse | ||||||||
| No relapse | 9 | 7 | 8 | 8 | ||||
| Relapse | 1 | 8 | 0.0405 | 0 | 8 | 0.022 | ||
Abbreviations: FTC: follicular thyroid carcinoma; CXCR4/7: C-X-C chemokine receptor type 4/7; UICC = Union internationale contre le cancer.