Table 12.
Analysis of gene data stratified by smoking level
| Smoking level | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Mild | Moderate | Severe | |||||||
| Gene | Genotype | OR (95%CI) | P-value | OR (95%CI) | P-value | OR (95%CI) | P-value | ||
| rs1047768 | CC | 1.00 | 1.00 | 1.00 | |||||
| TT | 0.87 (0.28-2.70) | 0.988 | 1.10 (0.35-3.45) | 0.996 | 0.40 (0.04-4.11) | 0.385 | |||
| CT | 0.75 (0.23-2.41) | 0.588 | 1.22 (0.38-3.92) | 0.699 | 0.54 (0.05-5.90) | 0.829 | |||
| rs1048943 | GG | 1.00 | 1.00 | 1.00 | |||||
| AA | 0.61 (0.17-2.15) | 0.384 | 0.49 (0.11-2.16) | 0.256 | 0.00 (0.00-I ) | 0.979 | |||
| GA | 0.74 (0.20-2.76) | 0.916 | 0.67 (0.14-3.16) | 0.920 | 0.00 (0.00-I ) | 0.983 | |||
| rs1052133 | CC | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.56 (0.19-1.59) | 0.648 | 0.74 (0.27-2.06) | 0.399 | 2.26 (0.52-9.88) | 0.589 | |||
| CG | 0.44 (0.15-1.24) | 0.151 | 1.04 (0.39-2.76) | 0.595 | 2.77 (0.65-11.81) | 0.274 | |||
| rs17655 | GG | 1.00 | 1.00 | 1.00 | |||||
| CC | 0.80 (0.32-2.01) | 0.806 | 1.12 (0.43-2.91) | 0.968 | 1.51 (0.30-7.53) | 0.802 | |||
| GC | 0.77 (0.34-1.76) | 0.673 | 1.29 (0.60-2.75) | 0.559 | 1.62 (0.44-5.90) | 0.602 | |||
| rs1801320 | CC | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.27 (0.02-3.19) | 0.357 | 0.00 (0.00-I ) | 0.984 | 0.00 (0.00-I ) | 0.981 | |||
| CG | 0.25 (0.02-3.09) | 0.298 | 0.00 (0.00-I ) | 0.983 | 0.00 (0.00-I ) | 0.979 | |||
| rs2298881 | GG | 1.00 | 1.00 | 1.00 | |||||
| TT | 1.20 (0.47-3.06) | 0.568 | 2.40 (0.91-6.29) | 0.201 | 0.95 (0.26-3.42) | 0.154 | |||
| GT | 0.89 (0.41-1.92) | 0.543 | 1.90 (0.88-4.09) | 0.554 | 5.55 (1.41-21.81) | 0.010 | |||
| rs3212961 | CC | 1.00 | 1.00 | 1.00 | |||||
| AA | 1.10 (0.43-2.80) | 0.821 | 2.43 (0.93-6.34) | 0.144 | 1.31 (0.36-4.80) | 0.681 | |||
| CA | 1.01 (0.44-2.34) | 0.923 | 1.73 (0.78-3.85) | 0.761 | 2.81 (0.83-9.51) | 0.109 | |||
| rs4771436 | GG | 1.00 | 1.00 | 1.00 | |||||
| TT | 0.96 (0.31-3.00) | 0.996 | 1.18 (0.43-3.26) | 0.604 | 0.78 (0.12-5.15) | 0.979 | |||
| GT | 0.91 (0.28-2.93) | 0.861 | 0.96 (0.34-2.71) | 0.743 | 0.59 (0.09-3.77) | 0.511 | |||
| rs7201 | CC | 1.00 | 1.00 | 1.00 | |||||
| AA | 0.92 (0.20-4.31) | 0.881 | 0.23 (0.02-2.16) | 0.254 | 1.36 (0.18-10.13) | 0.723 | |||
| CA | 0.97 (0.20-4.73) | 0.983 | 0.21 (0.02-2.08) | 0.210 | 2.87 (0.33-24.74) | 0.208 | |||
| rs9928731 | CC | 1.00 | 1.00 | 1.00 | |||||
| TT | 0.88 (0.34-2.23) | 0.679 | 1.83 (0.64-5.20) | 0.154 | 2.41 (0.55-10.50) | 0.443 | |||
| CT | 1.06 (0.46-2.44) | 0.714 | 0.94 (0.41-2.17) | 0.299 | 2.15 (0.62-7.44) | 0.548 | |||
| rs17577 | AA | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.22 (0.02-2.40) | 0.050 | 0.00 (0.00-I ) | 0.980 | 1.57 (0.08-29.60) | 0.664 | |||
| AG | 0.66 (0.06-7.66) | 0.634 | 0.00 (0.00-I ) | 0.979 | 1.20 (0.05-27.20) | 0.962 | |||
| rs2304277 | AA | 1.00 | 1.00 | 1.00 | |||||
| GG | 1.74 (0.65-4.61) | 0.088 | 1.27 (0.46-3.56) | 0.510 | 0.85 (0.18-3.91) | 0.884 | |||
| AG | 0.67 (0.31-1.43) | 0.053 | 0.87 (0.41-1.84) | 0.465 | 0.58 (0.19-1.79) | 0.397 | |||
| rs2928140 | GG | 1.00 | 1.00 | 1.00 | |||||
| CC | 0.88 (0.09-8.22) | 0.881 | 3.78 (0.37-38.09) | 0.390 | |||||
| GC | 1.09 (0.53-2.22) | 0.816 | 1.88 (0.89-3.97) | 0.960 | 1.67 (0.48-5.86) | 0.420 | |||
| rs3212964 | TT | 1.00 | 1.00 | 1.00 | |||||
| CC | 1.05 (0.43-2.55) | 0.927 | 0.97 (0.39-2.43) | 0.913 | 1.56 (0.42-5.75) | 0.843 | |||
| TC | 1.18 (0.52-2.71) | 0.677 | 1.02 (0.41-2.54 ) | 0.915 | 1.95 (0.54-7.03) | 0.407 | |||
| rs3787268 | AA | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.74 (0.27-2.06) | 0.293 | 0.53 (0.19-1.48) | 0.254 | 1.00 (0.20-5.05) | 0.571 | |||
| AG | 1.21 (0.44-3.29) | 0.355 | 0.64 (0.23-1.81) | 0.743 | 0.53 (0.10-2.66) | 0.262 | |||
| rs4646421 | AA | 1.00 | 1.00 | 1.00 | |||||
| GG | 0.55 (0.21-1.44) | 0.297 | 0.35 (0.12-1.05) | 0.284 | 0.29 (0.04-2.07) | 0.518 | |||
| AG | 0.66 (0.27-1.65) | 0.744 | 0.29 (0.10-0.81) | 0.047 | 0.21 (0.04-1.19) | 0.103 | |||
| rs4646422 | CC | 1.00 | 1.00 | 1.00 | |||||
| TT | 0.00 (0.00-14E84) | 0.918 | 0.31 (0.03-3.16) | 0.431 | 3E4 (0.00-1E253) | 0.971 | |||
| CT | 0.78 (0.38-1.61) | 0.921 | 0.63 (0.29-1.36) | 0.864 | 0.68 (0.19-2.49) | 0.970 | |||