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LASS2 inhibits Drp1 signaling through regulation of ERK pathway. LASS2 overexpression inhibited ERK phosphorylation in BIU87 and J82 cells while LASS2 depletion induced ERK phosphorylation in 5637 cells. Treatment with ERK inhibitor PD98059 in 5637 cells reduced p-Drp1 expression, abolishing the effect of LASS2 siRNA.
