Figure 2.

Comparative analysis of gene copy numbers in LUADs without EGFR mutations or ALK fusion. The copy numbers of 23 lung cancer-associate candidate genes were quantified in micro-dissected tumor cells and paired tumor-distant normal lung epithelial cells from ten LUAD patients without EGFR mutation or ALK fusion. The y-axis indicates the copy number index calculated by 2 × T_{copy number} / N_{copy number}, where T represents tumor cells and N is the tumor-distant normal lung epithelial cells. Each circle denotes one copy number index of the specified gene from one patient. * P < 0.05, tumor cells vs. paired tumor-distant normal epithelial cells, tested with the Mann-Whitney U test.