Figure 3.

Comparative analysis of expression for genes with lower copy numbers in LUAD. Gene expressions were measured in tumor cells and paired tumor-distant normal lung epithelial cells from ten LUAD patients without EGFR mutation or ALK fusion. A paired t test was used to evaluate the correlations of genes expression for PTEN (A), RB1 (B), HMGA2 (C) and PTPRD (D) between tumor tissues (T) and normal lung tissues (N). Each line with paired dot ends indicates the mRNA level change of one patient for the specified gene. P values, tumor cells vs. paired tumor-distant normal epithelial cells, were tested using the paired two-sample t test.