Figure 5.

eqSCIN blocks hemolysis in horses, humans, and pigs. eqSCIN is able to inhibit AP-dependent hemolysis of erythrocytes caused by the complement system of pigs (A), horses (B), and humans (C), whereas SCIN-A inhibits the complement system of only humans (C). As a control, HI serum did not lead to hemolysis of the erythrocytes. D, both SCIN-A and eqSCIN (concentration of 1 μm was used) do not significantly block hemolysis in mouse, rat, sheep, guinea pig, goat, and cow serum. Error bars, S.D.; n = 3. Significance relative to buffer control was determined by one-way ANOVA with Bonferroni post-test correction for multiple comparisons.