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Contribution of PAS domain on hERG mechanosensitivity. A, hERG1b currents show no response to laminar shear stress (mean ± S.D., p > 0.05, n = 7, paired t test). B, hERG1b co-transfected with 1–131 amino acids (PAS domain). Tail currents responded to shear stress (mean ± S.D., p < 0.05, n = 5, paired t test). C, response of heterotetrameric hERG1a/1b channels to laminar shear stress (mean ± S.D., p < 0.01, n = 7–8, paired t test). ns, non-significant.
