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. 2018 Jan 5;293(12):4289–4303. doi: 10.1074/jbc.RA117.000432

Figure 9.

Figure 9.

Shear sensitivity of hERG mutants. A, scatter plot shows response of N33T mutant to shear stress (mean ± S.D., p < 0.05, n = 7, paired t test). B, scatter plot shows response of R56Q mutant to shear stress (mean ± S.D., p > 0.05, n = 7, paired t test). C, scatter plot shows response of N588K mutant to shear stress. Both step (mean ± S.D., p < 0.001, n = 7, paired t test) and tail current (mean ± S.D., p < 0.001, n = 7, paired t test) showed significant increase in current during shear stress. ns, non-significant.