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. 2018 Jan 30;293(12):4498–4509. doi: 10.1074/jbc.RA117.000677

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Figure 4. — JADE1 selectively binds to H3/H4 over H2A/H2B and the nucleosome core particle. A, MBP-JADE1 pulldowns of HBO1 HAT and (H3/H4 or H2A/H2B) in the presence or absence of each other, with results resolved on SDS-PAGE. MW Std., molecular weight standard. B, MBP-JADE1 pulldowns of HBO1 HAT and H3/H4, H2A/H2B and mixtures of the two with results resolved on SDS-PAGE. C, MBP-JADE1 pulldowns of H3/H4 or nucleosome core particles with results resolved on SDS-PAGE. D, activity comparison of HBO1 HAT and HBO1 full-length in the presence and absence of a saturating concentration of JADE1(1–188) as either H3H4 complex or nucleosome core particles as the substrate. The activity of these proteins on various substrates was compared using radioactive counts.