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. 2017 Nov 4;67(2):226–236. doi: 10.1136/gutjnl-2017-314205

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This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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Microbial taxa associated with gastric carcinoma. (A) Cladogram representation of the gastric microbiota taxa associated with chronic gastritis and gastric carcinoma. (B) Association of specific microbiota taxa with the group of chronic gastritis and gastric carcinoma by linear discriminant analysis (LDA) effect size (LEfSe). Green indicates taxa enriched in chronic gastritis group and red indicates taxa enriched in gastric carcinoma group. (C) Relative abundance of the 10 genera differentially enriched in the two clinical settings across Portuguese discovery and Chinese validation cohorts. *Significance obtained by LEfSe analysis at P<0.05. (D,E) Validation of LEfSe results by quantitative PCR (qPCR) of the 10 genera differentially enriched in the discovery cohort (D) and in the Portuguese validation cohort (E). Significance was obtained by Student’s t-test.