Table 3.
| a – Overall survival and associations with clinicopathologic characteristics using Cox regression | |||
|---|---|---|---|
| Clinicopathologic variable | Total N | Hazard Ratio | p-value |
| L1-CAM expression (continuous) | 532 | 1.153 (1.076 – 1.236) | < 0.001 |
| L1-CAM expression (categorical, above or below median of 5.37) | 532 | 3.456 (1.968 – 6.071) | < 0.001 |
| Stage (I or II vs. III or IV) | 532 | 3.790 (2.269 – 6.329) | < 0.001 |
| Grade (Grade 1 or 2 vs. 3) | 532 | 4.333 (2.209 – 8.500) | < 0.001 |
| Peritoneal cytology (positive vs. negative) | 402 | 2.970 (1.643 – 5.371) | < 0.001 |
| Pelvic lymph nodes (positive vs. negative) | 532 | 2.112 (1.128 – 3.953) | 0.031 |
| Para-aortic lymph nodes (positive vs. negative) | 532 | 1.662 (0.665 – 4.153) | 0.31 |
| Histology (Serous vs. endometrioid) | 532 | 1.640 (1.277 – 2.105) | < 0.001 |
| Myometrial invasion (continuous %) | 460 | 1.024 (1.015 – 1.032) | < 0.001 |
| Myometrial invasion (deep vs. superficial) | 460 | 2.957 (1.686 – 5.184) | < 0.001 |
| Age (continuous) | 532 | 1.030 (1.007 – 1.054) | 0.011 |
| BMI (continuous) | 503 | 0.975 (0.947 – 1.005) | 0.088 |
| b - Multivariate survival model after variable selection | |||||
|---|---|---|---|---|---|
| HR | SE | p-val | Lower 95% |
Upper 95% |
|
| L1-CAM expression (categorical, above or below median of 5.37) | 4.572 | 2.26 | 0.002 | 1.736 | 12.046 |
| Myometrial invasion (continuous %) | 1.013 | 0.01 | 0.014 | 1.002 | 1.023 |
| Stage (I or II vs. III or IV) | 3.856 | 1.33 | < 0.001 | 1.957 | 7.598 |