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. Author manuscript; available in PMC: 2018 Mar 26.
Published in final edited form as: Arch Biochem Biophys. 2016 Oct 15;612:35–45. doi: 10.1016/j.abb.2016.10.008

Figure 1. Role of USP17 in cell-cycle regulation and cancer.

Figure 1

CDC25A is a cell-cycle phosphatase that promotes cell-cycle progression by dephosphorylating Cdk1. CDC25A cellular levels are regulated through ubiquitination that signals for CDC25A degradation. (A) In a normal cell, USP17 deubiquitinates and stabilizes CDC25A to promote cell-cycle progression [5]. (B) In cancer cells, USP17 levels are upregulated which results in increased deubiquitination and stabilization of CDC25A. The increased levels of CDC25A therefore result in cancer cell proliferation [5].