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. 2018 Mar 19;9:159. doi: 10.3389/fneur.2018.00159

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Copyright © 2018 Nazmi, Albertsson, Rocha-Ferreira, Zhang, Vontell, Zelco, Rutherford, Zhu, Nilsson, Mallard, Hagberg, Lai, Leavenworth and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rag1⁻^/⁻ mice are protected from hypoxia–ischemia (HI)-induced white-matter brain injury. (A,B) Representative images of MAP2 (A) and myelin basic protein (MBP) (B) immunostainings in wild-type (WT) and Rag1⁻^/⁻ mouse brain sections at 7 days after HI. (C) Higher magnification images of MBP staining in the subcortical white matter areas in the ipsilateral hemisphere. (D,E), Quantification of the MBP and microtubule-associated protein 2 (MAP-2) staining shows the percentage of tissue loss in the subcortical white matter (D) and gray matter (E) in WT (n = 18) and Rag1⁻^/⁻ mice (n = 18) at 7 days after HI insult. **p < 0.01 by Student’s unpaired t-test. Data are presented as the mean ± SEM.