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. 2018 Feb 13;39(4):1631–1639. doi: 10.3892/or.2018.6268

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 10. — PTEN inhibitor reduces the anticancer effects of miR-181 on the PTEN/PI3K/Akt/mTOR pathway of A549/DDP cells. The PTEN inhibitor reduced the anticancer effects of miR-181 overexpression on the promotion of PTEN protein expression and inhibition of PI3K, p-AKT and p-mTOR protein expression in A549/DDP cells, compared with the miR-181 overexpression group by (A) western blot analysis, and (B-D) by statistical analysis. Control, control negative group; anti-miR-181, miR-181 downregulation group; anti-miR-181 + PTEN inhibitor, miR-181 downregulation + PTEN inhibitor group. ^##p<0.01 vs. paracarcinoma tissue group; ^###p<0.01 vs. miR-181 downregulation group.