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Downregulation of miR-181 reduces PTEN/PI3K/Akt/mTOR pathway. miR-181 downregulation reduced PTEN protein expression and induced PI3K, p-AKT and p-mTOR protein expression in A549/DDP cells compared with the control group by (A) western blot analysis and (B-E) by statistical analysis. Control, control negative group; anti-miR-181, miR-181 downregulation group. ##p<0.01 vs. paracarcinoma tissue group.
