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. 2018 Feb 12;39(4):1649–1657. doi: 10.3892/or.2018.6259

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Copyright: © Cui et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miR-199a-3p enhances the sensitivity of ovarian cancer cell lines to cisplatin. (A and B) Effect of miR-199a-3p mimic or inhibitor on cell proliferation in SKOV3/CDDP cells was detected by CCK-8 assay, the concentration of CDDP used for SKOV3 or SKOV3/CDDP treatment was 0.75 or 2.03 µg/ml, respectively. (C and D) Cell apoptosis was detected by Annexin V-FITC/PI detection kit. (E and F) Cell cycle distribution was detected by PI staining and flow cytometry. (G and H) Cell invasion was detected by Transwell assay. Data shown are mean ± SD, *P<0.05, **P<0.01, compared with miR-NC (Student's t-test).

Figure 2. — miR-199a-3p enhances the sensitivity of ovarian cancer cell lines to cisplatin. (A and B) Effect of miR-199a-3p mimic or inhibitor on cell proliferation in SKOV3/CDDP cells was detected by CCK-8 assay, the concentration of CDDP used for SKOV3 or SKOV3/CDDP treatment was 0.75 or 2.03 µg/ml, respectively. (C and D) Cell apoptosis was detected by Annexin V-FITC/PI detection kit. (E and F) Cell cycle distribution was detected by PI staining and flow cytometry. (G and H) Cell invasion was detected by Transwell assay. Data shown are mean ± SD, *P<0.05, **P<0.01, compared with miR-NC (Student's t-test).