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. 2018 Feb 12;39(4):1649–1657. doi: 10.3892/or.2018.6259

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Copyright: © Cui et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Overexpression of ITGB8 enhances CDDP resistance in miR-199a-3p overexpressed ovarian cancer cells. SKOV3/CDDP/miR-199a-3p cells were transfected with pcDNA3.1-ITGB8 plasmid. (A) The transfection efficiency was validated by western blotting. (B) Cell proliferation was detected by CCK-8 assay. (C) Cell apoptosis was detected by Annexin V-FITC/PI detection kit. (D) Cell cycle distribution was detected by PI staining and flow cytometry. (E) Cell invasion was measured using the Transwell assay. Data shown are the representative images and quantitative data. Data shown are mean ± SD, *P<0.05, **P<0.01, compared with vector (Student's t-test).