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. 2018 Feb 7;39(4):1671–1681. doi: 10.3892/or.2018.6252

Figure 4.

Figure 4.

Yap modulates mitophagy via the SIRT1/Mfn2 pathways. (A-C) Change in SIRT1 and Mfn2 expression. Yap reduced the SIRT1 expression which alleviated the Mfn2 content. SRT (SRT1720), an activator of SIRT1, was used to reverse the SIRT1 expression in response to Yap deficiency. Restoration of SIRT1 reversed the Mfn2 expression. (D) The co-staining of SIRT1 and Mfn2. Loss of SIRT1 due to Yap deficiency was responsible for Mfn2 inactivation. (E-G) Recovery of SIRT1/Mfn2 pathways enhanced the expression of mitophagy markers, mito-LC3II, Atg5 and p62. *P<0.05 vs. the Ctrl group, #P<0.05 vs. the siRNA-Yap group. Yap, Yes-associated protein; Mfn2, mitofusin 2; SIRT1, Sirtuin 1; Atg5, autophagy protein 5.