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. 2018 Feb 7;39(4):1671–1681. doi: 10.3892/or.2018.6252

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Copyright: © Yan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — SIRT1/Mfn2 pathways are involved in mitochondrial homeostasis. (A) The change in cellular ATP content. Loss of Yap contributed to ATP deficiency which was inhibited via SIRT1 activation. (B and D) The change in mitochondrial membrane potential. (C) The mPTP opening rate. (E and F) The change in cellular oxidative markers. (H) Caspase-3 activity was used to demonstrate cellular viability. *P<0.05 vs. the Ctrl group, ^#P<0.05 vs. the siRNA-Yap group. Yap, Yes-associated protein; Mfn2, mitofusin 2; SIRT1, Sirtuin 1.