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. 2018 Mar 19;9:135. doi: 10.3389/fneur.2018.00135

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Copyright © 2018 Keane, Dietrich and de Rivero Vaccari.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inflammasome proteins in serum as biomarkers of multiple sclerosis (MS) severity. Protein levels in pg/ml of caspase-1 (A), apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) (B), and IL-18 (C) in serum samples from patients with MS and healthy donors. p-value of significance is shown above each box plot. Box and whiskers are shown for the fifth and 95^th percentile. Receiver operator characteristic curves for caspase-1 severity (mild vs. moderate) (D), ASC (E), and IL-18 (F). Caspase-1: N = 8 mild and 6 moderate; ASC: N = 13 mild and 8 moderate; and IL-18: N = 13 mild and 8 moderate.