Table 2.
Receiver operator characteristic analysis results for inflammasome signaling proteins in serum and cut-off point analyses for inflammasome signaling proteins in serum.
| Biomarker | Area | SE | 95% CI | P value | |
|---|---|---|---|---|---|
| Caspase-1 | 0.848 | 0.07394 | 0.703–0.9929 | 0.0034 | |
| Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) | 0.9448 | 0.02122 | 0.9032–0.9864 | <0.0001 | |
| IL-1 beta | 0.7619 | 0.0925 | 0.5806–0.9432 | 0.0318 | |
| IL-18 | 0.7075 | 0.05216 | 0.6052–0.8097 | 0.0003 | |
| Biomarker | Cut-off point (pg/ml) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
| Caspase-1 | >1.302 | 89 | 56 | 81 | 71 |
| ASC | >352.4 | 84 | 90 | 70 | 95 |
| IL-1 beta | <0.825 | 100 | 62 | 50 | 100 |
| IL-18 | >190.1 | 84 | 44 | 29 | 91 |