Table 3.

Receiver operator characteristic analysis results for inflammasome signaling proteins in serum and cut-off point analyses for inflammasome signaling proteins in serum as markers of multiple sclerosis severity (mild vs. moderate).

Biomarker	Area	SE	95% CI	P value
Caspase-1	0.6667	0.155	0.3629–0.9704	0.30
ASC	0.7596	0.11	0.5437–0.9756	0.05
IL-18	0.6346	0.12	0.3925–0.8767	0.31
Biomarker	Cut-off point (pg/ml)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
Caspase-1	>1.776	100	50	73	100
ASC	>537.5	75	62	76	60
IL-18	>238.2	88	54	75	73