Table 2.

COX Regression Analyses of Survival Associated with Presence of Circulating Tumor Cells

	Univariate			Multivariate
	Hazard Ratio	95% CI	Cox p value	Hazard Ratio	95% CI	Cox p value
Relapse-free survival
Primary tumor > 2 cm	4.79	2.15–10.66	<0.001	1.94	0.81–4.62	0.13
Pathologic node negative vs
1 to 3 lymph nodes	3.26	1.43–7.45	0.005	2.42	1.02–5.71	0.04
>3 Lymph nodes	12.97	6.09–27.6	<0.001	7.64	3.37–17.33	<0.001
Histologic grade 3	4.91	2.51–9.64	<0.001	2.56	1.18–5.55	0.02
Estrogen receptor positive	0.29	0.16–0.50	<0.001	0.92	0.43–1.97	0.82
Progesterone receptor positive	0.22	0.12–0.42	<0.001	0.53	0.22–1.30	0.17
HER2 positive	1.52	0.76–3.05	0.25	0.53	0.24–1.17	0.11
CTC≧1	2.72	1.57–4.72	<0.001	5.25	1.34–20.56	0.02
CTC≥2	3.12	1.52–6.41	0.001	–	–	–
CTC≥3	3.97	1.79–8.84	<0.001	–	–	–
Overall survival
Primary tumor > 2 cm	3.94	1.51–10.25	0.001	1.32	0.45–3.79	0.61
Pathologic node negative vs
1 to 3 lymph nodes	3.49	1.17–10.42	0.03	2.58	0.83–7.97	0.10
>3 Lymph nodes	13.36	4.92–36.24	<0.001	7.33	2.48–21.69	<0.001
Histologic grade 3	6.76	2.58–17.71	<0.001	3.27	1.11–9.63	0.03
Estrogen receptor positive	0.24	0.12–0.50	<0.001	0.67	0.24–1.84	0.44
Progesterone receptor positive	0.20	0.08–0.45	<0.001	0.57	0.17–1.91	0.37
HER2 positive	1.81	0.78–4.22	0.19	0.54	0.20–1.46	0.23
CTC≧1	2.29	1.12–4.67	0.02	1.62	0.75–3.48	0.22
CTC≥2	2.76	1.07–7.25	0.03	–	–	–
CTC≥3	4.88	1.87–12.73	<0.001	–	–	–