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(A) Bifunctional chelator and amino acid frameworks for preparing peptide-based dual-targeted imaging agents. (B) PET imaging of 68Ga-BBN-RGD in a GRPR- and integrin αvβ3–positive clinical prostate cancer patient (top) and doubly negative patient (bottom) (13). (C) PET images of U87MG-bearing mice (arrows) at 4 h after injection of indicated 64Cu-labeled tracers (8).
