FIGURE 1.

Delayed PET/CT-guided biopsy of bone metastasis from prostate carcinoma in 64-y-old man with strongly suspected metastatic prostate carcinoma (prostatic-specific antigen level, 91 ng/mL), without history of bone radiotherapy. (A) Axial CT scan shows suggestive increase in density (dashed arrow) on iliac bones. (B) Axial ⁸⁹Zr anti-PSMA–targeted PET/CT image shows new lesions on right iliac wing and sacrum (solid arrow). Interestingly, lesion identified on CT shows no uptake on PET (arrowhead). (C) Axial ⁸⁹Zr anti-PSMA–targeted PET/CT image 7 d after injection shows lesions, including the one that was biopsied. Pathologic examination confirmed metastasis from prostate carcinoma.