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. 2018 Mar;59(3):486–493. doi: 10.2967/jnumed.117.191221

FIGURE 2.

FIGURE 2.

Validation of PSMA expression in nonprostatic human cancer cell lines and xenografts. (A) PSMA gene expression in selected melanoma and lung cancer cell lines. (B) Flow cytometry of PSMA surface expression in PSMA-positive PC3 PIP, PSMA-negative PC3 flu, and nonprostatic cancer cell lines. PSMA-positive PC3 PIP is designed to overexpress copious amounts of PSMA. Mean fluorescence intensity quantification shows that PSMA-positive PC3 PIP has high level of PSMA surface expression whereas PSMA-negative PC3 flu, MeWo, and H69 are negative and DMS53, SKMEL24, and SKMEL3 are positive (right panel). (C) PSMA gene expression in selected melanoma and lung cancer xenografts. (D) PSMA total protein levels in selected melanoma and lung cancer xenografts and densitometric quantification (right panel).